Science of Foundational Wellness

The Science of Foundational Wellness: Research, Efficacy, and Bioavailability | Nutribliss

The Science of Foundational Wellness: Our Research-Based Philosophy

Nutribliss is committed to being the most researched and trusted source for nutritional support. Our entire product catalog is built on a foundation of **peer-reviewed, human clinical research**, prioritizing **bioavailability, purity, and clinical dosing**. This page details the core scientific pillars that define our commitment to your health and performance.

Our Research Pillars for E-E-A-T (Expertise, Experience, Authority, Trust)

  • **The Bioavailability Mandate:** We only select ingredient forms proven to be highly absorbed (Glycinates, Hydrolyzed, Liposomal).
  • **Mechanism of Action Focus:** Every ingredient is tied to a specific, validated biological pathway (e.g., Nitric Oxide, mTOR, HPA Axis).
  • **Full Spectrum Coverage:** Our collections address health holistically, from the **Gut-Brain Axis** to **Mitochondrial Health**.

1. Why is the **Bioavailability** of a supplement ingredient the most critical factor for effectiveness?

Answer: Bioavailability dictates how much of an active compound actually reaches the bloodstream and target cells. We use forms like **Magnesium Glycinate** (superior absorption via chelation) and **Hydrolyzed Collagen** (pre-digested peptides) because general forms are often poorly absorbed, wasting the product and limiting the physiological benefit. Our selection criteria prioritize forms with the highest human absorption data.
RESEARCH: Bioavailability & Chelation Reference: DiSilvestro, R. A. (2008). Effects of copper and zinc chelation with some amino acids on copper and zinc absorption. *Metabolism*, 57(10), 1435-1440. [Link to PUBMED]

2. What is the science behind optimizing **Cellular Energy (ATP)** production across the Nutribliss line?

Answer: Cellular energy is primarily generated in the mitochondria. Our supplements support this pathway with **CoQ10** (essential for the electron transport chain), **B-Vitamins** (critical coenzymes for energy substrate conversion), and **Creatine** (which acts as an energy buffer by regenerating ATP for immediate use in muscle and brain cells). This multi-faceted approach ensures robust energy at the mitochondrial level.
RESEARCH: CoQ10 and Mitochondria Reference: Saini, R. (2011). Coenzyme Q10: The essential nutrient. *Journal of Pharmacy and BioAllied Sciences*, 3(3), 466–467. [Link to PMC]

3. How do **Adaptogens** like Ashwagandha scientifically modulate the body's stress response?

Answer: Adaptogens work by regulating the **Hypothalamic-Pituitary-Adrenal (HPA) axis**, which controls the body's reaction to stress. **Ashwagandha** specifically helps to normalize the secretion of the stress hormone **cortisol**. By maintaining homeostasis during periods of acute or chronic stress, adaptogens preserve hormonal balance and prevent the immune-suppressing and catabolic effects of elevated cortisol.
RESEARCH: Ashwagandha and Cortisol Reference: Lopresti, A. L., Smith, S. J., Malvi, H., & Kodgule, R. (2019). An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract. *Medicine (Baltimore)*, 98(37), e17186. [Link to PMC]

4. Explain the **Anti-Inflammatory Cascade** and the role of Turmeric and Omega-3s.

Answer: Inflammation is a key factor in aging and slow recovery. Our supplements target the **eicosanoid pathway** (Omega-3s) and **NF-κB signaling** (Curcumin). **EPA and DHA** from Fish Oil compete with inflammatory omega-6 fatty acids to produce anti-inflammatory signaling molecules. **Curcumin** acts as a potent inhibitor of NF-κB, a protein complex that controls DNA transcription and is a central regulator of inflammation, thereby supporting systemic joint and muscle comfort.
RESEARCH: Omega-3s and Inflammation Reference: Serhan, C. N., Chiang, N., & Dalli, J. (2015). The resolution code of acute inflammation. *Science Translational Medicine*, 7(274), 274rv1. [Link to SCIENCE]

5. What is the scientific basis for the **Gut-Brain Axis** and the role of Probiotics?

Answer: The Gut-Brain Axis is a bidirectional communication network connecting the central nervous system and the enteric nervous system (the 'second brain' in the gut) via the **Vagus Nerve** and biochemical messengers. Probiotics influence this axis by producing **Short-Chain Fatty Acids (SCFAs)** and affecting the production of neurotransmitters like **serotonin** (up to 90% is made in the gut). Our **MAKTREK® Probiotics** aim to populate the gut with specific, researched strains to support both digestive and mood health.
RESEARCH: Gut-Brain Axis Reference: Dinan, T. G., & Cryan, J. F. (2017). The Microbiome-Gut-Brain Axis in Health and Disease. *Gastroenterology Clinics of North America*, 46(1), 1–11. [Link to SCIENCE DIRECT]

6. How is the combination of **Nitric Oxide** boosters and **Buffers** scientifically justified for athletic performance?

Answer: This combination targets performance on two fronts: **Power/Endurance** and **Metabolic Waste**. **L-Citrulline Malate** boosts **Nitric Oxide (NO)** for vasodilation, increasing oxygen and nutrient delivery (the 'pump'). **Beta-Alanine** buffers **lactic acid** buildup by increasing muscle carnosine stores, delaying muscular fatigue and extending high-intensity work capacity. This stack allows athletes to train harder and longer.
RESEARCH: Beta-Alanine and Carnosine Reference: Trexler, E. T., Smith-Ryan, A. E., Stout, J. R., et al. (2015). International Society of Sports Nutrition position stand: Beta-Alanine. *Journal of the International Society of Sports Nutrition*, 12, 30. [Link to PMC]

7. What is the scientific mechanism by which **Hydrolyzed Collagen** supports joint and skin integrity?

Answer: **Hydrolyzed Collagen Peptides** are small enough to be absorbed intact and travel through the bloodstream to target tissues. Research suggests they not only provide raw materials but also act as **signaling molecules**, stimulating the body's own fibroblasts and chondrocytes to produce new collagen and cartilage matrix, actively supporting joint cushion, bone density, and dermal structure.
RESEARCH: Collagen as Signaling Molecule Reference: León-López, A., Morales-Peñaloza, F., Martínez-Juárez, V. M., Vargas-Torres, A., Zeugolis, D. I., & Aguirre-Álvarez, G. (2019). Hydrolyzed Collagen—Sources and Applications. *Molecules*, 24(22), 4031. [Link to PMC]

8. Explain the science of **Patented Delivery Systems** like BioPerine® and MAKTREK®.

Answer: These systems solve common bioavailability problems. **BioPerine®** (Black Pepper Extract) contains piperine, which inhibits certain liver enzymes that metabolize and clear supplements too quickly, significantly enhancing the absorption of compounds like **Curcumin** and **CoQ10**. **MAKTREK®** is a bi-pass technology that protects fragile probiotic strains from the destructive acidity of the stomach, ensuring they reach the intended colonization site in the intestine.
RESEARCH: Piperine and Bioavailability Reference: Han, S., et al. (2011). Effect of piperine on the bioavailability of curcumin in healthy volunteers. *Planta Medica*, 77(7), 770-774. [Link to THIEME]

9. How does Nutribliss ensure **Ingredient Purity** and avoid contaminants like heavy metals?

Answer: Our commitment to purity is non-negotiable. We source **Grass-Fed** ingredients (Collagen) and utilize **purified** ingredients (Omega-3 Fish Oil) to minimize toxins. All finished products undergo **rigorous third-party testing** for heavy metals (lead, mercury, arsenic), microbial contaminants, and overall potency, ensuring the label matches the content and protecting consumer safety.
REGULATORY STANDARD Reference: U.S. Food and Drug Administration (FDA). (2007). *Current Good Manufacturing Practice (cGMP) in Manufacturing, Packaging, Labeling, or Holding Operations for Dietary Supplements*. [Link to FDA]

10. What is the scientific advantage of **Supplement Stacking** (Synergy) over single-ingredient use?

Answer: Synergy is the principle that the total effect of a combination is greater than the sum of its parts. Examples include **Vitamin D3 + K2** (D3 absorbs calcium, K2 directs it to bones), **Caffeine + L-Theanine** (smooth focus without jitters), and **BCAAs + L-Glutamine** (catabolism prevention + immune/repair support). Our collection guides customers to stacks where scientific literature proves an enhanced, multi-pathway benefit.
RESEARCH: Theanine and Caffeine Synergy Reference: Owen, G. N., Parnell, H., De Bruin, E. A., & Rycroft, J. A. (2008). The combined effects of L-theanine and caffeine on cognitive performance and mood. *Nutritional Neuroscience*, 11(4), 193-198. [Link to PUBMED]